The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection.

ABSTRACT:

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in patients. Methodology. Forty-five SARS-CoV-2 infected patients and another random control group of 45 healthy individuals were included. The detection of ACE I/D gene polymorphism in both groups was done by PCR.

Results

53% of infected patients with SARS-CoV-2 had an ACE deletion/deletion

SUBMITTER: El-Sayed Marei Y 

PROVIDER: S-EPMC9833908 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature