Unknown

Dataset Information

0

The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection.


ABSTRACT:

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in patients. Methodology. Forty-five SARS-CoV-2 infected patients and another random control group of 45 healthy individuals were included. The detection of ACE I/D gene polymorphism in both groups was done by PCR.

Results

53% of infected patients with SARS-CoV-2 had an ACE deletion/deletion genotype (D/D), 27% had an ACE deletion/insertion genotype (D/I), and 20% had an ACE insertion/insertion genotype (I/I). On the one hand, the D/D variant was significantly detected in the COVID-19 patients compared to the control subjects, whereas the I/I variant was significantly detected in the control subjects compared to the COVID-19 patients (p = 0.004). The D/D variant subgroup showed the lowest lymphocytic count compared to the D/I or I/I subgroups. In addition, the C-reactive protein was significantly higher and the oxygen saturation was significantly lower in patients with the D/D allele compared to the other subgroups.

Conclusions

ACE gene polymorphism, particularly the DD genotype, was observed to affect the severity of COVID-19 infection.

SUBMITTER: El-Sayed Marei Y 

PROVIDER: S-EPMC9833908 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection.

El-Sayed Marei Yara Y   Abdallah Bayoumy Ahmed A   Mohamed Abulazm Nassar Hassnaa H   Mansour Bassam B   Bakeir Hamady Asmaa A  

International journal of microbiology 20230104


<h4>Introduction</h4>The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in pat  ...[more]

Similar Datasets

| S-EPMC10612096 | biostudies-literature
| S-EPMC10335690 | biostudies-literature
| S-EPMC10881620 | biostudies-literature
| S-EPMC10925588 | biostudies-literature
| S-EPMC7201219 | biostudies-literature
| S-EPMC9364667 | biostudies-literature
| S-BSST563 | biostudies-other
2022-03-01 | E-MTAB-10970 | biostudies-arrayexpress
| S-EPMC8415730 | biostudies-literature
| S-EPMC8815985 | biostudies-literature