Specific polysubstance use patterns predict relapse among patients entering opioid use disorder treatment.

ABSTRACT:

Introduction

While polysubstance use has consistently been associated with higher rates of relapse, few studies have examined subgroups with specific combinations and time course of polysubstance use (i.e., polysubstance use patterns). This study aimed to classify and compare polysubstance use patterns, and their associations with relapse to regular opioid use in 2637 participants in three large opioid use disorder (OUD) treatment trials.

Methods

We explored the daily patterns of self-reported substance use in the 28 days prior to treatment entry. Market basket analysis (MBA) and repeated measure latent class analysis (RMLCA) were used to examine the subgroups of polysubstance use patterns, and multiple logistic regression was used to examine associations between identified

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9838120 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature