Effect of GATAD1 regulating the SRRM2 gene on recurrence of thyroid tumor and its molecular mechanism.

ABSTRACT:

Background

Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.

Methods

Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of GATAD1 as well as SRRM2 on the recurrence of THCA patients. The effect of GATAD1 on SRRM2 expression was explored using cell experiments. Other experiments were conducted to reveal the interaction b

SUBMITTER: Wang X 

PROVIDER: S-EPMC9841002 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature