Interventions to address polypharmacy in older adults living with multimorbidity: Review of reviews.

ABSTRACT:

Objective

To summarize evidence from published systematic reviews evaluating the effect of polypharmacy interventions on clinical and intermediate outcomes. It also summarizes the adverse events that may occur as a result of these interventions.

Data sources

A literature search was conducted using the electronic databases MEDLINE, Embase, CINAHL, Cochrane Central, and Cochrane Database of Systematic Reviews (PROSPERO registration number: CRD42018085767).

Study selection

The search yielded a total of 21,329 citations, of which 619 were reviewed as full text and 5 met the selection criteria.

Synthesis

The polypharmacy interventions were found to produce statistically significant reductions in potentially inappropriate prescribing and improved medication adherence

SUBMITTER: Ali MU 

PROVIDER: S-EPMC9842141 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature