Dataset Information

Depression, perceived stress, and distress during pregnancy and EV-associated miRNA profiles in MADRES.

ABSTRACT:

Background

MicroRNA (miRNA) circulating in plasma has been proposed as biomarkers for a variety of diseases and stress measures, including depression, stress, and trauma. However, few studies have examined the relationship between stress and miRNA during pregnancy.

Methods

In this study, we examined associations between measures of stress and depression during pregnancy with miRNA in early and late pregnancy from the MADRES cohort of primarily low-income Hispanic women based in Los Angeles, California. Extracellular-vesicle- (EV-) associated miRNA were isolated from maternal plasma and quantified using the Nanostring nCounter platform. Correlations for stress-associated miRNA were also calculated for 89 matching cord blood samples.

Results

Fifty miRNA were nominally associated with depression, perceived stress, and prenatal distress (raw p < 0.05) with 17 miRNA shared between two or more stress measures. Two miRNA (miR-150-5p and miR-148b-3p) remained marginally significant after FDR adjustment (p < 0.10). Fifteen PANTHER pathways were enriched for predicted gene targets of the 50 miRNA associated with stress. Clusters of maternal and neonate miRNA expression suggest a link between maternal and child profiles.

Limitations

The study evaluated 142 miRNA and was not an exhaustive analysis of all discovered miRNA. Evaluations for stress, depression and trauma were based on self-reported instruments, rather than diagnostic tools.

Conclusions

Depression and stress during pregnancy are associated with some circulating EV miRNA. Given that EV miRNA play important roles in maternal-fetal communication, this may have downstream consequences for maternal and child health, and underscore the importance of addressing mental health during pregnancy, especially in health disparities populations.

SUBMITTER: Foley HB

PROVIDER: S-EPMC9844263 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Depression, perceived stress, and distress during pregnancy and EV-associated miRNA profiles in MADRES.

Foley Helen Bermudez HB Howe Caitlin G CG Eckel Sandrah P SP Chavez Thomas T Gevorkian Lili L Reyes Eileen Granada EG Kapanke Bethany B Martinez Danilo D Xue Shanyan S Suglia Shakira F SF Bastain Theresa M TM Marsit Carmen C Breton Carrie V CV

Journal of affective disorders 20221220

<h4>Background</h4>MicroRNA (miRNA) circulating in plasma has been proposed as biomarkers for a variety of diseases and stress measures, including depression, stress, and trauma. However, few studies have examined the relationship between stress and miRNA during pregnancy.<h4>Methods</h4>In this study, we examined associations between measures of stress and depression during pregnancy with miRNA in early and late pregnancy from the MADRES cohort of primarily low-income Hispanic women based in Lo ...[more]

PMID: 36563790

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Dataset Information

Depression, perceived stress, and distress during pregnancy and EV-associated miRNA profiles in MADRES.

Background

Methods

Results

Limitations

Conclusions

Publications

Depression, perceived stress, and distress during pregnancy and EV-associated miRNA profiles in MADRES.

Similar Datasets

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