Montreal Cognitive Assessment Predicts the Short‐Term Risk of Lewy Body Disease in Isolated REM Sleep Behavior Disorder with Reduced MIBG Scintigraphy

ABSTRACT: Abstract

Background

Long‐term follow‐up of isolated rapid eye movement (REM) sleep behavior disorder (IRBD) patients reveals a high risk of α‐synucleinopathies.

Objective

We explored the early clinical predictive factors of phenoconversion from IRBD to Parkinson's disease (PD) or dementia with Lewy bodies (DLB).

Methods

We assessed baseline office‐based cognitive test scores (Montreal Cognitive Assessment [MoCA‐J], Mini‐Mental State Examination [MMSE], and Frontal Assessment Battery [FAB]), motor function, and olfactory function in 36 consecutive polysomnography (PSG)‐confirmed IRBD patients with reduced metaiodobenzylguanidine (MIBG) accumulation. PD or DLB was confirmed by medical chart review retrospectively.

Results

Of 36 IRBD patients, 19 (n = 19, 5

SUBMITTER: Miyamoto M 

PROVIDER: S-EPMC9847289 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature