Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis.

ABSTRACT:

Objectives

Balancing the risks of hypotension and vasopressor-associated adverse effects is a daily challenge in ICUs. We conducted a systematic review with meta-analysis to examine the effect of lower versus higher exposure to vasopressor therapy on mortality among adult ICU patients with vasodilatory hypotension.

Data sources

We searched Ovid Medline, Embase, and the Cochrane Central Register of Controlled Trials for studies published from inception to October 15, 2021.

Study selection

We included randomized controlled trials of lower versus higher exposure to vasopressor therapy in adult ICU patients with vasodilatory hypotension without language or publication status limits.

Data extraction

The primary outcome was 90-day all-cause mortality, with seven pres

SUBMITTER: Richards-Belle A 

PROVIDER: S-EPMC9848218 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature