Serum Bicarbonate and Graft and Patient Outcomes Among Kidney Transplant Recipients: A Retrospective Cohort Study Evaluating Changes in Serum Bicarbonate Over Time.

ABSTRACT:

Rationale & objective

Identification of treatable risk factors for kidney allograft failure is necessary to improve graft longevity. Metabolic acidosis with either low serum bicarbonate or normal serum bicarbonate (eubicarbonatemic metabolic acidosis) is implicated in native kidney disease progression but its effects in kidney transplant recipients are unclear.

Study design

Retrospective cohort study.

Setting & participants

An Integrated Claims-Clinical dataset of US patients with chronic kidney disease (estimated glomerular filtration rates <60 mL/min/1.73 m²) and serum bicarbonate data were used to generate a cohort of kidney transplant recipients with data from ≥1 year before and after transplantation.

Primary predictor

The primary independent var

SUBMITTER: Mathur V 

PROVIDER: S-EPMC9850186 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature