Study of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients.

ABSTRACT:

Introduction

An inflammatory environment is the common pathway for the development of cholangiocarcinoma (CCA). The natural killer group 2D receptor (NKG2D), an activating receptor for NK cells, is a potent immune axis in the antitumor and antimicrobial immune response through its binding to NKG2D ligands (NKG2DLs). NKG2DLs are normally absent or poorly expressed in most cells; conversely, they are upregulated in stressed cells. We studied the rs2596542 polymorphism located upstream of the MICA gene, which encodes an NKG2DL, in patients with CCA as a marker for early disease detection and a possible therapeutic target.

Material and methods

A case-control study was conducted on 40 patients with CCA and 45 healthy individuals (as controls). After routine examination, th

SUBMITTER: Abdel-Rahman AA 

PROVIDER: S-EPMC9850301 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature