Dataset Information

Study of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients.

ABSTRACT:

Introduction

An inflammatory environment is the common pathway for the development of cholangiocarcinoma (CCA). The natural killer group 2D receptor (NKG2D), an activating receptor for NK cells, is a potent immune axis in the antitumor and antimicrobial immune response through its binding to NKG2D ligands (NKG2DLs). NKG2DLs are normally absent or poorly expressed in most cells; conversely, they are upregulated in stressed cells. We studied the rs2596542 polymorphism located upstream of the MICA gene, which encodes an NKG2DL, in patients with CCA as a marker for early disease detection and a possible therapeutic target.

Material and methods

A case-control study was conducted on 40 patients with CCA and 45 healthy individuals (as controls). After routine examination, the rs2596542 polymorphism of the MICA gene was investigated using real-time PCR.

Results

We found that a TT homozygous genotype was significantly predominant in patients with CCA (p = 0.039), with the T allele being dominantly distributed in CCA (p = 0.007). High levels of CA19-9 were significantly associated with the TT genotype in the patients. However, we did not detect significant differences in rs2596542C/T genotype and allele distribution between patients with CCA with cirrhosis and those without cirrhosis (p > 0.05).

Conclusions

The MICA rs2596542 polymorphism may affect the susceptibility to CCA, but not its progression. The TT genotype could be used as a potential diagnostic marker for CCA and triggering the MICA pathway could be a promising therapeutic target.

SUBMITTER: Abdel-Rahman AA

PROVIDER: S-EPMC9850301 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Study of the association between a <i>MICA</i> gene polymorphism and cholangiocarcinoma in Egyptian patients.

Abdel-Rahman Adel A-H AA Farag Moshera Abdallah Hassan MAH Naguib Mary M Abdelsameea Eman E Abdel-Bary Hamed M HM

Clinical and experimental hepatology 20221228 4

<h4>Introduction</h4>An inflammatory environment is the common pathway for the development of cholangiocarcinoma (CCA). The natural killer group 2D receptor (NKG2D), an activating receptor for NK cells, is a potent immune axis in the antitumor and antimicrobial immune response through its binding to NKG2D ligands (NKG2DLs). NKG2DLs are normally absent or poorly expressed in most cells; conversely, they are upregulated in stressed cells. We studied the rs2596542 polymorphism located upstream of t ...[more]

PMID: 36683874

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