Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.

ABSTRACT: Nutritional influences have been discussed as potential modulators of Parkinson's disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calories leads to accelerated disease onset and progression. The underlying molecular mechanisms of HFD-induced aggravated pathology, however, remain largely unclear. In this study, we aimed to further illuminate the effects of a fat-enriched diet in PD by examining the brainstem and hippocampal transcriptome of alpha-synuclein transgenic mice exposed to a life-long HFD. Investigating individual transcript isoforms, differential gene expression and co-expression clusters, we observed that transcriptional differences between wild-type (WT) and transgenic

SUBMITTER: Kilzheimer A 

PROVIDER: S-EPMC9851747 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature