Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity.
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ABSTRACT:
SUBMITTER: Smederevac S
PROVIDER: S-EPMC9852709 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Differences in <i>MB-COMT</i> DNA methylation in monozygotic twins on phenotypic indicators of impulsivity.
Smederevac Snežana S Delgado-Cruzata Lissette L Mitrović Dušanka D Dinić Bojana M BM Bravo Toni-Ann T TT Delgado Maria M Bugarski Ignjatović Vojislava V Sadiković Selka S Milovanović Ilija I Vučinić Nataša N Branovački Bojan B Prinz Mechthild M Budimlija Zoran Z Kušić-Tišma Jelena J Nikolašević Željka Ž
Frontiers in genetics 20230106
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (<i>MB</i>-<i>COMT</i>) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used p ...[more]
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