Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients.

ABSTRACT: Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7-350] pg/mL,

SUBMITTER: Gomez-Bernal F 

PROVIDER: S-EPMC9855909 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature