Necroptosis Related Genes Predict Prognosis and Therapeutic Potential in Gastric Cancer.

ABSTRACT: The clinical significance of necroptosis in gastric cancer (GC) has yet to be fully elucidated. The purpose of our study was to identify a necroptosis-relevant gene and to establish a prediction model to estimate the prognosis and therapeutic potential in GC. Here, we explored the expression profile of 76 necroptosis-related genes in TCGA-STAD patients. A six-gene risk score prediction model was established via regression analysis of the least absolute shrinkage and selection operator (LASSO) and validated in a separate cohort. Patients were separated into low- or high-risk groups according to the median risk score. We then compared and analyzed the biological process characteristics of two risk groups. Additionally, cell-to-cell communications and metabolic activity were analyzed in a sin

SUBMITTER: Wu N 

PROVIDER: S-EPMC9856014 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature