Evaluation of Endocan as a Treatment for Acute Inflammatory Respiratory Failure.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a life-threatening condition resulting from acute pulmonary inflammation. However, no specific treatment for ARDS has yet been developed. Previous findings suggest that lung injuries related to ARDS could be regulated by endocan (Esm-1). The aim of this study was to evaluate the potential efficiency of endocan in the treatment of ARDS.

Methods

We first compared the features of acute pulmonary inflammation and the severity of hypoxemia in a tracheal LPS-induced acute lung injury (ALI) model performed in knockout (Esm1^-/-) and wild type (WT) littermate C57Bl/6 mice. Next, we assessed the effects of a continuous infusion of glycosylated murine endocan in our ALI model in Esm1^-/- mice.

SUBMITTER: Hureau M 

PROVIDER: S-EPMC9857156 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature