Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity.

ABSTRACT:

Background

Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood.

Methods

To address this, we comprehensively interrogated cellular and soluble elements of the immune system by using high-dimensional flow cytometry to analyze peripheral blood mononuclear cells and performing cytokine/chemokine profiling of serum samples, respectively, in a cohort of 69 patients and 19 non-CKD controls.

Results

Altered serum levels of several cytokines/chemokines were identified, among which concentrations of stem cell factor (SCF) were found to be elevated with the progression of CKD and inversely correlated with estimated glomerular filtr

SUBMITTER: Wu IW 

PROVIDER: S-EPMC9871851 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature