Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution.

ABSTRACT:

Background

Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available. However, only a subgroup of metastases uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The distinct mode of vascularization is reflected by specific histopathological growth patterns (HGPs), which have proven prognostic and predictive significance. Nevertheless, their molecular mechanisms are poorly understood.

Methods

We evaluated CRCLM from 225 patients regarding their HGP and clinical data. Moreover, we performed spatial (21,804 spots) and single-cell (22,419

SUBMITTER: Fleischer JR 

PROVIDER: S-EPMC9872436 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature