CDCA3 is a prognostic biomarker for cutaneous melanoma and is connected with immune infiltration.

ABSTRACT:

Introduction

Dysregulation of cell cycle progression (CCP) is a trait that distinguishes cancer from other diseases. In several cancer types, CCP-related genes serve as the primary risk factor for prognosis, but their role in cutaneous melanoma remains unclear.

Methods

Data from cutaneous melanoma patients were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Using a Wilcoxon test, the level of CCP-related gene expression in cutaneous melanoma patient tissues was compared to that in normal skin tissues. Logistic analysis was then utilized to calculate the connection between the CCP-related genes and clinicopathological variables. The important functions of the CCP-related genes were further investigated using Gene Ontology (GO), Kyoto Encyclope

SUBMITTER: Li T 

PROVIDER: S-EPMC9876620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature