HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirao Preto (SP), Brazil. Cross-sectional study.

ABSTRACT:

Background

Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women.

Design and setting

Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.

Methods

This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was perf

SUBMITTER: Pimenta ATM 

PROVIDER: S-EPMC9879551 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature