Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients.

ABSTRACT:

Background

Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery.

Study design and methods

In this study, we analyzed the concentrations of selected plasma cytokines (i.e., IL-6, IP-10, IL-10, IL-22, IFNγ, GM-CSF, IL-8) and M. tuberculosis sputum burden in patients with tuberculosis (n = 76). Cytokine levels were compared to healthy contacts (n = 40) and changes under treatment were monitored (i.e., 6 and 16 weeks after treatment start). According to differences in M. tuberculosis sputu

SUBMITTER: Vivekanandan MM 

PROVIDER: S-EPMC9879809 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature