Unconstrained quantitative magnetization transfer imaging: disentangling <i>T</i> ₁ of the free and semi-solid spin pools.

ABSTRACT: Since the inception of magnetization transfer (MT) imaging, it has been widely assumed that Henkelman's two spin pools have similar longitudinal relaxation times, which motivated many researchers to constrain them to each other. However, several recent publications reported a T1s of the semi-solid spin pool that is much shorter than T1f of the free pool. While these studies tailored experiments for robust proofs-of-concept, we here aim to quantify the disentangled relaxation processes on a voxel-by-voxel basis in a clinical imaging setting, i.e., with an effective resolution of 1.24mm isotropic and full brain coverage in 12min. To this end, we optimized a hybrid-state pulse sequence for mapping the parameters of an unconstrained MT model. We scanned four people with re

SUBMITTER: Asslander J 

PROVIDER: S-EPMC9882584 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature