Dataset Information

A User-Friendly Computational Framework for Robust Structured Regression with the L₂ Criterion.

ABSTRACT: We introduce a user-friendly computational framework for implementing robust versions of a wide variety of structured regression methods with the L₂ criterion. In addition to introducing an algorithm for performing L₂E regression, our framework enables robust regression with the L₂ criterion for additional structural constraints, works without requiring complex tuning procedures on the precision parameter, can be used to identify heterogeneous subpopulations, and can incorporate readily available non-robust structured regression solvers. We provide convergence guarantees for the framework and demonstrate its flexibility with some examples. Supplementary materials for this article are available online.

SUBMITTER: Chi JT

PROVIDER: S-EPMC9886233 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

A User-Friendly Computational Framework for Robust Structured Regression with the L2 Criterion.

Chi Jocelyn T JT Chi Eric C EC

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America 20220324 4

We introduce a user-friendly computational framework for implementing robust versions of a wide variety of structured regression methods with the L2 criterion. In addition to introducing an algorithm for performing L2E regression, our framework enables robust regression with the L2 criterion for additional structural constraints, works without requiring complex tuning procedures on the precision parameter, can be used to identify heterogeneous subpopulations, and ...[more]

PMID: 36721836

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Project description:Functional data are increasingly encountered in scientific studies, and their high dimensionality and complexity lead to many analytical challenges. Various methods for functional data analysis have been developed, including functional response regression methods that involve regression of a functional response on univariate/multivariate predictors with nonparametrically represented functional coefficients. In existing methods, however, the functional regression can be sensitive to outlying curves and outlying regions of curves, so is not robust. In this paper, we introduce a new Bayesian method, robust functional mixed models (R-FMM), for performing robust functional regression within the general functional mixed model framework, which includes multiple continuous or categorical predictors and random effect functions accommodating potential between-function correlation induced by the experimental design. The underlying model involves a hierarchical scale mixture model for the fixed effects, random effect and residual error functions. These modeling assumptions across curves result in robust nonparametric estimators of the fixed and random effect functions which down-weight outlying curves and regions of curves, and produce statistics that can be used to flag global and local outliers. These assumptions also lead to distributions across wavelet coefficients that have outstanding sparsity and adaptive shrinkage properties, with great flexibility for the data to determine the sparsity and the heaviness of the tails. Together with the down-weighting of outliers, these within-curve properties lead to fixed and random effect function estimates that appear in our simulations to be remarkably adaptive in their ability to remove spurious features yet retain true features of the functions. We have developed general code to implement this fully Bayesian method that is automatic, requiring the user to only provide the functional data and design matrices. It is efficient enough to handle large data sets, and yields posterior samples of all model parameters that can be used to perform desired Bayesian estimation and inference. Although we present details for a specific implementation of the R-FMM using specific distributional choices in the hierarchical model, 1D functions, and wavelet transforms, the method can be applied more generally using other heavy-tailed distributions, higher dimensional functions (e.g. images), and using other invertible transformations as alternatives to wavelets.

Dataset Information

A User-Friendly Computational Framework for Robust Structured Regression with the L₂ Criterion.

Publications

A User-Friendly Computational Framework for Robust Structured Regression with the L<sub>2</sub> Criterion.

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