Comparative effect of stenting plus medical therapy vs medical therapy alone on the risk of stroke and death in patients with symptomatic intracranial stenosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Recently, several randomized controlled trials (RCTs) of stenting plus medical therapy versus medical therapy alone have been successfully conducted for the treatment of patients with symptomatic intracranial stenosis. This study aimed to evaluate differences between these two therapies in the risk of stroke and death.

Methods

MEDLINE, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systematically searched to identify relevant studies published before August 24, 2022. Review Manager 5.3 software was used to assess the data. The risk ratio (RR) was analysed and calculated with a random effect model or a fixed effects model.

Results

We pooled 921 participants from three RCTs. Compared to the medical therapy alone group, the stenting plus medical the

SUBMITTER: Wu X 

PROVIDER: S-EPMC9886616 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature