Functional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways.

ABSTRACT: Adenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor showing a propensity for delayed recurrence, with decreased survival rates. The identification of poor prognosis patients may help in defining molecular-based targeted strategies in this rare disease orphan of new treatments. Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. Patients who experienced early relapse showed enrichment in proliferation-related gene sets, including the G2-M checkpoint, E2F and myc targets, and in gene sets related to IFN signaling and aberrant proteostasis (FDR < 0.1), indicating increased mitotic and transcriptional activity in aggressive ACC. Sim

SUBMITTER: Romani C 

PROVIDER: S-EPMC9889376 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature