Cancer detection in clinical practice and using blood-based liquid biopsy: A retrospective audit of over 350 dogs.

ABSTRACT:

Background

Guidelines-driven screening protocols for early cancer detection in dogs are lacking, and cancer often is detected at advanced stages.

Hypothesis/objectives

To examine how cancer typically is detected in dogs and whether the addition of a next-generation sequencing-based "liquid biopsy" test to a wellness visit has the potential to enhance cancer detection.

Animals

Client-owned dogs with definitive cancer diagnoses enrolled in a clinical validation study for a novel blood-based multicancer early detection test.

Methods

Retrospective medical record review was performed to establish the history and presenting complaint that ultimately led to a definitive cancer diagnosis. Blood samples were subjected to DNA extraction, library preparation, and next-gen

SUBMITTER: Flory A 

PROVIDER: S-EPMC9889684 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature