C(sp³)-H cyanation by a formal copper(iii) cyanide complex.

ABSTRACT: High-valent metal oxo complexes are prototypical intermediates for the activation and hydroxylation of alkyl C-H bonds. Substituting the oxo ligand with other functional groups offers the opportunity for additional C-H functionalization beyond C-O bond formation. However, few species aside from metal oxo complexes have been reported to both activate and functionalize alkyl C-H bonds. We herein report the first example of an isolated copper(iii) cyanide complex (LCu^IIICN) and its C-H cyanation reactivity. We found that the redox potential (E _ox) of substrates, instead of C-H bond dissociation energy, is a key determinant of the rate of PCET, suggesting an oxidative asynchronous CPET or ETPT mechanism. Among substrates with the same BDEs, those with low redox pot

SUBMITTER: Bower JK 

PROVIDER: S-EPMC9891353 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature