Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.

ABSTRACT: Neurons tightly regulate firing rate and a failure to do so leads to multiple neurological disorders. Therefore, a fundamental question in neuroscience is how neurons produce reliable activity patterns for decades to generate behavior. Neurons have built-in feedback mechanisms that allow them to monitor their output and rapidly stabilize firing rate. Most work emphasizes the role of a dominant feedback system within a neuronal population for the control of moment-to-moment firing. In contrast, we find that respiratory motoneurons use 2 activity-dependent controllers in unique combinations across cells, dynamic activation of an Na+ pump subtype, and rapid potentiation of Kv7 channels. Both systems constrain firing rate by reducing excitability for up to a minute after a burst of action pote

SUBMITTER: Pellizzari S 

PROVIDER: S-EPMC9894548 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature