Subcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenously produced gaseous signaling molecule with important roles in regulating organelle function and stress. Because of its high reactivity, targeted delivery of H₂S using small molecule H₂S donors has garnered significant interest to minimize off-target effects. Although mitochondrially targeted H₂S donors, such as AP39, have been reported previously and exhibit significantly higher potency than nontargeted donors, the expansion of targeted H₂S delivery to other subcellular organelles remains largely absent. To fill this key unmet need, we report a library of organelle-targeted H₂S donors that localize H₂S delivery to specific subcellular organelles, including the Golgi apparatu

SUBMITTER: Gilbert AK 

PROVIDER: S-EPMC9896967 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature