Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.

ABSTRACT: Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10^-9). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to th

SUBMITTER: Akiyama M 

PROVIDER: S-EPMC9898503 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature