Ontology highlight
ABSTRACT: Conclusion
Glucose-to-lactate ratio on day 1 may represent a new risk marker for infants with HIE undergoing TH.What is known
• Glucose and lactate are key metabolic fuels during neonatal hypoglycemia. This suggests that their concentrations may influence the neurodevelopmental outcome of neonates experiencing hypoxic-hischemic encephalopathy (HIE).What is new
• We describe the relative availbility of glucose and lactate before and during theraputic hypothermia in neonates with HIE.
SUBMITTER: Galderisi A
PROVIDER: S-EPMC9899169 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Galderisi Alfonso A Tordin Mattia M Suppiej Agnese A Cainelli Elisa E Baraldi Eugenio E Trevisanuto Daniele D
European journal of pediatrics 20221209 2
We aimed to assess the glucose and lactate kinetics during therapeutic hypothermia (TH) in infants with hypoxic-ischemic encephalopathy and its relationship with longitudinal neurodevelopment. We measured glucose and lactate concentrations before TH and on days 2 and 3 in infants with mild, moderate, and severe hypoxic-ischemic encephalopathy (HIE). Neurodevelopment was assessed at 2 years. Participants were grouped according to the neurodevelopmental outcome into favorable (FO) or unfavorable ( ...[more]