Genome-wide association study meta-analysis of suicide death and suicidal behavior.

ABSTRACT: Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10^-8 before and p = 4.55 × 10^-8 after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantly change the a

SUBMITTER: Li QS 

PROVIDER: S-EPMC9908547 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature