Peroxide-cleavable linkers for antibody-drug conjugates.

ABSTRACT: Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro.

SUBMITTER: Ashman N 

PROVIDER: S-EPMC9910056 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature