Early developmental trajectory of children with prenatal alcohol and opioid exposure.

ABSTRACT:

Background

With significant increases in opioid use/misuse and persistent high prevalence of prenatal alcohol exposure (PAE), identifying infants at risk for long-term developmental sequelae due to these exposures remains an urgent need. This study reports on developmental outcomes in young children from a prospective cohort, ENRICH-1, which recruited pregnant women and followed up maternal-infant pairs.

Methods

Subjects were assigned to four study groups based on prenatal use of medications for opioid use disorder (MOUD), PAE, MOUD+PAE, and unexposed controls (UC). Mixed effects modeling was used to evaluate changes in the Bayley Scales of Infant Development-III (BSID-III) Cognitive, Language, and Motor scores between 6 and 20 months.

Results

There was a significant

SUBMITTER: Lowe JR 

PROVIDER: S-EPMC9911560 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature