Single-time-point dosimetry using model selection and nonlinear mixed-effects modelling: a proof of concept.

ABSTRACT:

Purpose

This project aims to develop and evaluate a method for accurately determining time-integrated activities (TIAs) in single-time-point (STP) dosimetry for molecular radiotherapy. It performs a model selection (MS) within the framework of the nonlinear mixed-effects (NLME) model (MS-NLME).

Methods

Biokinetic data of [¹¹¹In]In-DOTATATE activity in kidneys at T1 = (2.9 ± 0.6) h, T2 = (4.6 ± 0.4) h, T3 = (22.8 ± 1.6) h, T4 = (46.7 ± 1.7) h, and T5 = (70.9 ± 1.0) h post injection were obtained from eight patients using planar imaging. Eleven functions were derived from various parameterisations of mono-, bi-, and tri-exponential functions. The functions' fixed and random effects parameters were fitted simultaneously (in the NLME framework) to the biokinetic data

SUBMITTER: Hardiansyah D 

PROVIDER: S-EPMC9911583 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature