In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus.

ABSTRACT:

Introduction

Surveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.

Methods

In this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin.

Results

In vitro experiments showed that monolaurin inhibited viral replication by up to 80%, while in vivo studies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of infla

SUBMITTER: Su B 

PROVIDER: S-EPMC9911909 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature