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A mathematical model of protein subunits COVID-19 vaccines.

ABSTRACT: We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-γ and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analysis, show that a balance between the T_H1 and T_H2 arms of the immune response is struck, with the T_H1 response being dominant. The model predicts that two-doses of the vaccine at 28 days apart will result in approximately 85% humoral immunity loss relative to peak immunity approximately 6 months post dose 1.

SUBMITTER: Gholami S

PROVIDER: S-EPMC9911981 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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A mathematical model of protein subunits COVID-19 vaccines.

Gholami Samaneh S Korosec Chapin S CS Farhang-Sardroodi Suzan S Dick David W DW Craig Morgan M Ghaemi Mohammad Sajjad MS Ooi Hsu Kiang HK Heffernan Jane M JM

Mathematical biosciences 20230210

We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-γ and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analy ...[more]

PMID: 36773843

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