Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease Induces Functional Brain Changes.

ABSTRACT:

Background

Cognitive behavioral therapy (CBT) reduces anxiety symptoms in patients with Parkinson's disease (PD).

Objective

The objective of this study was to identify changes in functional connectivity in the brain after CBT for anxiety in patients with PD.

Methods

Thirty-five patients with PD and clinically significant anxiety were randomized over two groups: CBT plus clinical monitoring (10 CBT sessions) or clinical monitoring only (CMO). Changes in severity of anxiety symptoms were assessed with the Parkinson Anxiety Scale (PAS). Resting-state functional brain MRI was performed at baseline and after the intervention. Functional networks were extracted by an Independent Component Analysis (ICA). Functional connectivity (FC) changes between structures involved in th

SUBMITTER: Carey G 

PROVIDER: S-EPMC9912714 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature