Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer's Disease.

ABSTRACT:

Background

First-degree relatives of individuals with late-onset Alzheimer's disease (AD) have increased risk for AD, with children of affected parents at an especially high risk.

Objective

We aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in cognitively healthy (CH) individuals with (FH+) and without (FH-) a family history of AD, alongside amnestic mild cognitive impairment (aMCI) and AD individuals, to determine the context and directionality of dysfunction in at-risk individuals. Our primary hypothesis was that there would be a linear decline (CH FH- > CH FH+ > aMCI > AD) within the risk groups on all measures of AD risk.

Methods

We used MRI and fMRI to study cognitively healthy individuals (n = 28) with and wit

SUBMITTER: Green ZD 

PROVIDER: S-EPMC9912732 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature