Bacillus subtilis Modulated the Expression of Osteogenic Markers in a Human Osteoblast Cell Line.

ABSTRACT: Several in vivo trials have previously demonstrated the beneficial effects of the administration of various probiotic forms on bone health. In this study, we explored the potency of two probiotics, Bacillus subtilis and Lactococcus lactis, alone or in combination with vitamin D (VD), to modulate the transcription of genes involved in the ossification process in a human osteoblast cell line. Genes that mark the "osteoblast proliferation phase", such as RUNX2, TGFB1, and ALPL, "extracellular matrix (ECM) maturation", such as SPP1 and SPARC, as well as "ECM mineralization", such as BGN, BGLAP, and DCN, were all highly expressed in osteoblasts treated with B. subtilis extract. The observed increase in the transcriptio

SUBMITTER: Sojan JM 

PROVIDER: S-EPMC9913848 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature