Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies.

ABSTRACT: The gut microbiome is increasingly being recognized as an important immunologic environment, with direct links to the host immune system. The scale of the gut microbiome's genomic repertoire extends the capacity of its host's genome by providing additional metabolic output, and the close communication between gut microbiota and mucosal immune cells provides a continued opportunity for immune education. The relationship between the gut microbiome and the host immune system has important implications for oncologic disease, including lymphoma, a malignancy derived from within the immune system itself. In this review, we explore past and recent discoveries describing the role that bacterial populations play in lymphomagenesis, diagnosis, and therapy. We highlight key relationships within the g

SUBMITTER: Upadhyay Banskota S 

PROVIDER: S-EPMC9916782 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature