Synthesis, In Silico Study, Antibacterial and Antifungal Activities of N-phenylbenzamides.

ABSTRACT: Antibiotic and antifungal resistance problems have been prevalent in recent decades. One of the efforts to solve the problems is to develop new medicines with more potent antibacterial and antifungal activity. N-phenylbenzamides have the potential to be developed as antibacterial and antifungal medicine. This study aimed to synthesize N-phenylbenzamides and evaluate their in silico and in vitro antibacterial and antifungal activities. The in silico studies conducted absorption, distribution, metabolism, excretion and toxicity (ADMET) predictions along with molecular docking studies. ADMET predictions used pkCSM software online, while the docking studies used MVD software (Molegro ^® Virtual Docker version 5.5) on Aminoglycosid-2 ″-phosphotransferase-IIa (APH2 ″-IIa)

SUBMITTER: Sulistyowaty MI 

PROVIDER: S-EPMC9917131 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature