Collagen deposition within brain metastases is associated with leptomeningeal failure after 
cavity-directed radiosurgery.

ABSTRACT:

Background

Leptomeningeal failure (LMF) represents a devastating progression of disease following resection of brain metastases (BrM). We sought to identify a biomarker at time of BrM resection that predicts for LMF using mass spectrometry-based proteomic analysis of resected BrM and to translate this finding with histochemical assays.

Methods

We retrospectively reviewed 39 patients with proteomic data available from resected BrM. We performed an unsupervised analysis with false discovery rate adjustment (FDR) to compare proteomic signature of BrM from patients that developed LMF versus those that did not. Based on proteomic analysis, we applied trichrome stain to a total of 55 patients who specifically underwent resection and adjuvant radiosurgery. We used competing risks r

SUBMITTER: Abdulhaleem M 

PROVIDER: S-EPMC9918843 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature