Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.

ABSTRACT: Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca²⁺-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. TRPA1 channels are endogenously activated by lipid peroxide metabolites generated by reactive oxygen species (ROS). Uncontrolled hypertension, a primary risk factor for the development of hemorrhagic stroke, is associated with increased ROS production and oxidative stress. Therefore, we hypothesized that TRPA1 channel activity is increased during hemorrhagic stroke. Methods: Severe, chronic hypertension was induced in control (Trpa1 ^fl/fl) and endothelia

SUBMITTER: Sullivan MN 

PROVIDER: S-EPMC9922848 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature