Weight Loss, Lifestyle Intervention, and Metformin Affect Longitudinal Relationship of Insulin Secretion and Sensitivity.

ABSTRACT:

Context

Insulin secretion and sensitivity regulate glycemia, with inadequately compensated deficiencies leading to diabetes.

Objective

We investigated effects of weight loss, an intensive lifestyle intervention (ILS), and metformin on the relationship between insulin secretion and sensitivity using repository data from 2931 participants in the Diabetes Prevention Program clinical trial in adults at high risk of developing type 2 diabetes.

Methods

Insulin secretion and sensitivity were estimated from insulin and glucose concentrations in fasting and 30-minute postload serum samples at baseline and 1, 2, and 3 years after randomization, during the active intervention phase. The nonlinear relationship of secretion and sensitivity was evaluated by standardized major axis

SUBMITTER: Vazquez Arreola E 

PROVIDER: S-EPMC9923796 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature