An endogenous amniotic fluid-derived 10-amino acid peptide improves lung development and hyperoxia injury.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that occurs in preterm infants and lacks effective treatment. We aim to reveal the relationship between amniotic fluid (AF) peptides and lung development by analyzing the differences in the composition of AF peptides at different gestational periods, thus providing a new means of prevention and treatment for BPD.

Methods

Based on the stages of lung development, we collected AF by amniocentesis in two different gestational periods, using the 25th week of pregnancy as the cut-off. We conducted a peptide omics analysis of these AF samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Additionally, we verified the regulatory effects of hyperoxia and the peptide COL5A2 on BPD-related

SUBMITTER: Li B 

PROVIDER: S-EPMC9926127 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature