Characteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021.

ABSTRACT:

Objective

To evaluate the recent practice of design and statistical analysis of ophthalmic randomized clinical trials (RCTs).

Design

Review of 96 ophthalmic RCTs.

Methods

Two authors (R.D., G.S.Y.) reviewed primary result papers published from January 2020 through December 2021 in Ophthalmology, JAMA Ophthalmology, American Journal of Ophthalmology, and British Journal of Ophthalmology. Data were extracted and analyzed for the characteristics of design (1-eye design, 2-eye design, paired-eye design, and subject design), sample size and power, and statistical analysis for intereye correlation adjustment, missing data, and correction for multiplicity.

Main outcome measures

Characteristics of trial design and statistical analysis.

Re

SUBMITTER: Dong R 

PROVIDER: S-EPMC9926296 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature