Cancer metabolic features allow discrimination of tumor from white blood cells by label-free multimodal optical imaging.

ABSTRACT: Circulating tumor cells (CTCs) are tumor cells that have penetrated the circulatory system preserving tumor properties and heterogeneity. Detection and characterization of CTCs has high potential clinical values and many technologies have been developed for CTC identification. These approaches remain challenged by the extraordinary rarity of CTCs and the difficulty of efficiently distinguishing cancer from the much larger number of white blood cells in the bloodstream. Consequently, there is still a need for efficient and rapid methods to capture the broad spectrum of tumor cells circulating in the blood. Herein, we exploit the peculiarities of cancer metabolism for discriminating cancer from WBCs. Using deuterated glucose and Raman microscopy we show that a) the known ability of cancer ce

SUBMITTER: Mangini M 

PROVIDER: S-EPMC9928723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature