A magnetic resonance imaging-based computational analysis of cerebral hemodynamics in patients with carotid artery stenosis.

ABSTRACT: Management of asymptomatic carotid artery stenosis (CAS) relies on measuring the percentage of stenosis. The aim of this study was to investigate the impact of CAS on cerebral hemodynamics using magnetic resonance imaging (MRI)-informed computational fluid dynamics (CFD) and to provide novel hemodynamic metrics that may improve the understanding of stroke risk. CFD analysis was performed in two patients with similar degrees of asymptomatic high-grade CAS. Three-dimensional anatomical-based computational models of cervical and cerebral blood flow were constructed and calibrated patient-specifically using phase-contrast MRI flow and arterial spin labeling perfusion data. Differences in cerebral hemodynamics were assessed in preoperative and postoperative models. Preoperatively, patient 1 dem

SUBMITTER: Schollenberger J 

PROVIDER: S-EPMC9929419 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature