Ozone reduces ischemic damage after a stroke by regulating the autophagy of astrocytes.

ABSTRACT:

Background

Stroke is a common and damaging disease of brain tissue, and has high morbidity, disability, and mortality rates. Ozone (O₃) is an isomer of oxygen and can be applied to ozonate the isolated blood in specific containers outside the body and return it to the body. O₃ can also alter the activity and function of multiple cellular components, thus affecting blood viscosity and altering hemodynamics. However, the question of whether O₃ has clinical value in the treatment of stroke requires further investigation. This study sought to evaluate the protective effect and possible mechanism of O₃ in brain injury after stroke.

Methods

First, oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human glioblastoma cell (A172) and

SUBMITTER: Huang N 

PROVIDER: S-EPMC9929848 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature