Reinstatement of Pavlovian responses to alcohol cues by stress.

ABSTRACT:

Rationale

Stress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models of stress-induced reinstatement generally use contingent presentations of alcohol-paired cues to reinforce instrumental behaviors, making it difficult to isolate the ability of cues to invigorate alcohol-seeking.

Objective

Here we sought to test the impact of stress on behavioral responses to alcohol-paired cues, using a model of stress-induced reinstatement of Pavlovian conditioned approach, inspired by Nadia Chaudhri's work on context-induced reinstatement.

Methods

Long Evans rats were trained to associate one auditory cue with delivery of alcohol or sucrose and an alternative auditory cue with no reward. Following ex

SUBMITTER: Armstrong A 

PROVIDER: S-EPMC9931652 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature