Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts.

ABSTRACT:

Background

Polygenic risk score (PRS) has been demonstrated to be effective in identifying individuals at high risk of developing cancer, but its prognostic value remains unclear.

Methods

We constructed site-specific PRSs by aggregating the risk effect of independent variants derived from previous genome-wide association studies (GWASs) across 17 cancer types. The Cox proportional hazards model was used to evaluate the association of each PRS with cancer survival, leveraging data from two prospective European cohorts, namely the UK Biobank involving 19,628 incident cases and The Cancer Genome Atlas involving 7079 prevalent cases. The combined PRS (CPRS), determined by merging site-specific PRSs, was further used to assess the prognostic effect of PRS on overall cancer in a s

SUBMITTER: Xin J 

PROVIDER: S-EPMC9931923 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature